Title : Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways.

Pub. Date : 2015

PMID : 25997958






5 Functional Relationships(s)
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1 Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways. Capsaicin mitogen-activated protein kinase 8 Homo sapiens
2 We also found that capsaicin induced JNK and p38 MAPK phosphorylation. Capsaicin mitogen-activated protein kinase 8 Homo sapiens
3 JNK and p38 MAPK inhibitor effectively blocked capsaicin-induced SMMC-7721 cell apoptosis. Capsaicin mitogen-activated protein kinase 8 Homo sapiens
4 In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin. Capsaicin mitogen-activated protein kinase 8 Homo sapiens
5 Our results indicate that capsaicin induced in SMMC-7721 cell apoptosis through generation of intracellular ROS and activation of JNK and p38 MAPK pathways. Capsaicin mitogen-activated protein kinase 8 Homo sapiens