Pub. Date : 2015
PMID : 25997958
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways. | Capsaicin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We also found that capsaicin induced JNK and p38 MAPK phosphorylation. | Capsaicin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | JNK and p38 MAPK inhibitor effectively blocked capsaicin-induced SMMC-7721 cell apoptosis. | Capsaicin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin. | Capsaicin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Our results indicate that capsaicin induced in SMMC-7721 cell apoptosis through generation of intracellular ROS and activation of JNK and p38 MAPK pathways. | Capsaicin | mitogen-activated protein kinase 8 | Homo sapiens |