Title : ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese ischemic stroke patients.

Pub. Date : 2015 Feb

PMID : 25997249






10 Functional Relationships(s)
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1 ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese ischemic stroke patients. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
2 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
3 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
4 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
5 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
6 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
7 P-glycoprotein (P-gp) encoded by ABCB1, a transmembrane calcium-dependent efflux pump for clopidogrel, implicated a role in clopidogrel resistance. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
8 In this present study, we investigated the methylation status of ABCB1 gene promoter in relation to ABCB1 mRNA expressions and the antiplatelet effects of clopidogrel. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
9 In conclusions, hypomethylation of ABCB1 promoter is associated with a decreased response to clopidogrel in ischemic stroke patients via increased ABCB1 mRNA expression. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens
10 In conclusions, hypomethylation of ABCB1 promoter is associated with a decreased response to clopidogrel in ischemic stroke patients via increased ABCB1 mRNA expression. Clopidogrel ATP binding cassette subfamily B member 1 Homo sapiens