Title : The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage.

Pub. Date : 2015 May 20

PMID : 25992485






1 Functional Relationships(s)
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1 IL-1beta, COX-2-dependent PGE2 activated the PI3-K/AKT and p38 signaling pathways, which were in turn responsible for MMP-1 synthesis via NF-kappaB- and c-Jun-transactivating pathways. Dinoprostone interleukin 1 beta Homo sapiens