Title : Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.

Pub. Date : 2015 Sep

PMID : 25989210






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. Dactinomycin tumor protein p53 Homo sapiens
2 Actinomycin D promotes phosphorylation and accumulation of p53 via a mechanism that involves high expression of MDM2. Dactinomycin tumor protein p53 Homo sapiens
3 We hypothesized that co-treatment of cells with actinomycin D and nutlin-3a would lead to synergistic activation of p53 by stimulating kinases and preventing accumulated MDM2 from binding to p53. Dactinomycin tumor protein p53 Homo sapiens
4 We hypothesized that co-treatment of cells with actinomycin D and nutlin-3a would lead to synergistic activation of p53 by stimulating kinases and preventing accumulated MDM2 from binding to p53. Dactinomycin tumor protein p53 Homo sapiens
5 Indeed, co-treatment of various cell lines with actinomycin D and nutlin-3a resulted in a synergistic increase of p53 phosphorylation on serine 46. Dactinomycin tumor protein p53 Homo sapiens