Pub. Date : 2015 Sep
PMID : 25989210
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 2 | Actinomycin D promotes phosphorylation and accumulation of p53 via a mechanism that involves high expression of MDM2. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 3 | We hypothesized that co-treatment of cells with actinomycin D and nutlin-3a would lead to synergistic activation of p53 by stimulating kinases and preventing accumulated MDM2 from binding to p53. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 4 | We hypothesized that co-treatment of cells with actinomycin D and nutlin-3a would lead to synergistic activation of p53 by stimulating kinases and preventing accumulated MDM2 from binding to p53. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 5 | Indeed, co-treatment of various cell lines with actinomycin D and nutlin-3a resulted in a synergistic increase of p53 phosphorylation on serine 46. | Dactinomycin | tumor protein p53 | Homo sapiens |