Title : Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway.

Pub. Date : 2015 Jun

PMID : 25982794






3 Functional Relationships(s)
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1 Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
2 Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
3 Taken together, these findings suggest that CBG can act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens