Title : The Use of Transporter Probe Drug Cocktails for the Assessment of Transporter-Based Drug-Drug Interactions in a Clinical Setting-Proposal of a Four Component Transporter Cocktail.

Pub. Date : 2015 Sep

PMID : 25981193






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Furosemide was evaluated in vitro, and is a substrate of OAT1 and OAT3, with Km values of 38.9 and 21.5 muM, respectively. Furosemide latexin Homo sapiens
2 Furosemide inhibited BCRP (50% inhibition of drug transport: 170 muM), but did not inhibit OATP1B1, OATP1B3, OCT2, MATE1, and MATE2-K at concentrations below 300 muM, and P-gp at concentrations below 2000 muM. Furosemide latexin Homo sapiens