Title : Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.

Pub. Date : 2015 May 20

PMID : 25980580






1 Functional Relationships(s)
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1 Targeted metabolomics studies revealed that the ability of metformin to interfere with the anaplerotic entry of glutamine into the tricarboxylic acid cycle could explain the hypersensitivity of IDH1-mutant cells to biguanides. Tricarboxylic Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens