Pub. Date : 2015 Mar 10
PMID : 25976054
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: A dose of 2.5 microg/L IL-1beta induced the protein expressions of cPLA2 and COX-2 and a subsequent release of PGE2 in a time-dependent manner. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 2 | Both SB203580 and PD98059 inhibitors reduced IL-1beta-induced PGE2 production while SB203580 alone reduced the expressions of both cPLA2 and COX-2. | Dinoprostone | interleukin 1 beta | Homo sapiens |
| 3 | CONCLUSION: IL-1beta induces the expressions of cPLA2 and COX-2 and affects COX-2 at the post-translational level by modulating PGE2 production through the signal transduction pathways of p38 and p42/44 MAPKs. | Dinoprostone | interleukin 1 beta | Homo sapiens |