Pub. Date : 2015 Sep
PMID : 25970160
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: It is known that over expression of IL6 in prostate cancer cells confer enzalutamide resistance and that this may occur through constitutive Stat3 activation. | enzalutamide | interleukin 6 | Homo sapiens |
| 2 | Knock down of Stat3 abrogated enzalutamide resistance resulting in reduced recruitment of AR to the PSA promoter in prostate cancer cells expressing IL6. | enzalutamide | interleukin 6 | Homo sapiens |
| 3 | CONCLUSIONS: This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. | enzalutamide | interleukin 6 | Homo sapiens |
| 4 | Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. | enzalutamide | interleukin 6 | Homo sapiens |