Pub. Date : 2015 Jun
PMID : 25967074
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinical significance of CYP2C9-status guided valproic acid therapy in children. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Thus, patients" CYP2C9-status may account for the predisposition to adverse reactions, and testing CYP2C9-status may contribute to the improvement and rationalization of VPA therapy in children. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | When the results of CYP2C9 genotyping and CYP2C9 expression were combined, the patients" VPA-metabolizing capacity was predicted, and VPA dosing was adjusted to the patients" CYP2C9-status. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | When the results of CYP2C9 genotyping and CYP2C9 expression were combined, the patients" VPA-metabolizing capacity was predicted, and VPA dosing was adjusted to the patients" CYP2C9-status. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | When the results of CYP2C9 genotyping and CYP2C9 expression were combined, the patients" VPA-metabolizing capacity was predicted, and VPA dosing was adjusted to the patients" CYP2C9-status. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 6 | SIGNIFICANCE: The knowledge of pediatric patients" CYP2C9-status can contribute to the optimization of VPA dosing and to the avoidance of misdosing-induced side effects. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |