Pub. Date : 2015 Aug 1
PMID : 25963742
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | BACKGROUND: CYP2E1 is a versatile phase I drug-metabolizing enzyme responsible for the biotransformation of most volatile organic compounds, including toluene. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | Human toluene exposure increases CYP2E1 mRNA and modifies its activity in leucocytes; however, epigenetic implications of this interaction have not been investigated. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 4 | GOAL: To determine promoter methylation of CYP2E1 and other genes known to be affected by toluene exposure. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 5 | RESULTS: In exposed group we found significant correlations between toluene airborne levels and CYP2E1 promoter methylation (r=-.36, p<0.05), as well as for IL6 promoter methylation levels (r=.44, p<0.05). | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 6 | Moreover, CYP2E1 promoter methylation levels where higher in toluene-exposed smokers compared to nonsmokers (p=0.009). | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 7 | CONCLUSION: These results highlight the importance of considering CYP2E1 epigenetic modifications, as well as its interactions with other genes, as key factors for unraveling the sub cellular mechanisms of toxicity exerted by oxidative stress, which can initiate disease process in chronic, low-level toluene exposure. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 8 | People co-exposed to toluene and tobacco smoke are in higher risk due to a possible CYP2E1 repression. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |