Title : Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer.

Pub. Date : 2015 Jun 20

PMID : 25962959






2 Functional Relationships(s)
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1 Dinaciclib, a novel small molecule inhibitor of CDK1, CDK2, CDK5 and CDK9, is assessed in clinical trials for the treatment of several types of cancers. dinaciclib cyclin dependent kinase 1 Homo sapiens
2 Dinaciclib alone actively induced cell growth inhibition, cell cycle arrest and apoptosis with the increased intracellular ROS levels, which were accompanied by obvious alterations of related proteins such as CDKs, Cyclins, Mcl-1, XIAP and survivin. dinaciclib cyclin dependent kinase 1 Homo sapiens