Title : Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury.

Pub. Date : 2015

PMID : 25962073






3 Functional Relationships(s)
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1 HSPB1 promoter activity as well as messenger RNA and protein expression indicated dose-dependent induction by H2O2. Hydrogen Peroxide heat shock protein family B (small) member 1 Rattus norvegicus
2 Furthermore, H2O2-induced autophagy was inhibited by the transfection of small interfering RNAs for HSPB1. Hydrogen Peroxide heat shock protein family B (small) member 1 Rattus norvegicus
3 Overexpression of HSPB1 reduced BAX activation and H2O2-induced apoptosis, as measured by caspase 3 activity and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay. Hydrogen Peroxide heat shock protein family B (small) member 1 Rattus norvegicus