Title : Effect of Melatonin on the Extracellular-Regulated Kinase Signal Pathway Activation and Human Osteoblastic Cell Line hFOB 1.19 Proliferation.

Pub. Date : 2015 May 7

PMID : 25961946






2 Functional Relationships(s)
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1 Western blot demonstrated that 10 microM melatonin significantly promoted ERK1/2 phosphorylation. Melatonin mitogen-activated protein kinase 3 Homo sapiens
2 In conclusion, this study for the first time indicates that melatonin (10 nM-100 microM) promotes the proliferation of a human osteoblastic cell line hFOB 1.19 through activation of c-Raf, MEK1/2, ERK1/2, p90RSK and MSK1. Melatonin mitogen-activated protein kinase 3 Homo sapiens