Title : Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate.

Pub. Date : 2016 Feb 25

PMID : 25961931






1 Functional Relationships(s)
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1 In the present study we exposed a series of p53 wild-type human cancer cell lines to drugs such as actinomycin D (ActD), doxorubicin, 5-fluorouracil and CX-5461, which hinder ribosomal RNA (rRNA) synthesis. Fluorouracil tumor protein p53 Homo sapiens