Pub. Date : 2015 Jun 10
PMID : 25961827
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 2 | Here, we found that activated AKT signaling is associated with rapamycin resistance in breast and colon cancers by sustained phosphorylation of the translational repressor 4E-BP1. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |
| 3 | Treatment of tumor cells with rapamycin or the AKT inhibitor MK2206 showed a limited activity in inhibiting 4E-BP1 phosphorylation, cap-dependent translation, cell growth and motility. | Sirolimus | eukaryotic translation initiation factor 4E binding protein 1 | Homo sapiens |