Title : Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Pub. Date : 2015 Aug 21

PMID : 25961497






1 Functional Relationships(s)
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1 This study examines the specificity and mechanism of action of a recently reported hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase-protease inhibitor (HPI), and the interaction of HPI with the NS3 protease inhibitors telaprevir, boceprevir, danoprevir, and grazoprevir. telaprevir KRAS proto-oncogene, GTPase Homo sapiens