Pub. Date : 2015 Aug
PMID : 25959547
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because Abeta interacts with Zn(2+) and Cu(2+), it is likely that these metal ions are involved in the Abeta-induced modification of the synaptic function. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 2 | Because Abeta interacts with Zn(2+) and Cu(2+), it is likely that these metal ions are involved in the Abeta-induced modification of the synaptic function. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 3 | There is evidence to indicate that the inhibition of the interaction of Abeta with Zn(2+) and Cu(2+) may ameliorate the pathophysiology of AD. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 4 | Interaction of extracellular Zn(2+) with Abeta in the hippocampus is involved in transiently Abeta-induced cognition deficits, while the interaction of extracellular Cu(2+) reduces bioavailability of intracellular Cu(2+), followed by an increase in oxidative stress, which may lead to cognitive deficits. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 5 | Interaction of extracellular Zn(2+) with Abeta in the hippocampus is involved in transiently Abeta-induced cognition deficits, while the interaction of extracellular Cu(2+) reduces bioavailability of intracellular Cu(2+), followed by an increase in oxidative stress, which may lead to cognitive deficits. | Zinc | amyloid beta precursor protein | Homo sapiens |
| 6 | It is likely that Zn(2+) and Cu(2+) play as a key-mediating factor in pathophysiology of the synaptic dysfunction in which Abeta is involved. | Zinc | amyloid beta precursor protein | Homo sapiens |