Pub. Date : 2015 Aug
PMID : 25954860
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | It has been demonstrated that most chemotherapy drugs exert their anti-cancer effects via p53-mediated apoptosis, and in accordance, with this, the present study showed that treatment with etoposide significantly increased p53 levels. | Etoposide | tumor protein p53 | Homo sapiens |
2 | It has been demonstrated that most chemotherapy drugs exert their anti-cancer effects via p53-mediated apoptosis, and in accordance, with this, the present study showed that treatment with etoposide significantly increased p53 levels. | Etoposide | tumor protein p53 | Homo sapiens |
3 | This was further verified in CCRCC tissue specimens from patients The results of the present study suggested that loss of PTEN, which deactivated Akt/HDM2 signaling followed by degradation of p53, may contribute to the development of etoposide resistance in CCRCC. | Etoposide | tumor protein p53 | Homo sapiens |