Title : Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.

Pub. Date : 1989 Dec 22

PMID : 2595372






1 Functional Relationships(s)
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1 Cyclosporin A was found to specifically inhibit the appearance of DNA binding activity of NF-AT, AP-3, and to a lesser extent NF-kappa B, nuclear proteins that appear to be important in the transcriptional activation of the genes for interleukin-2 and its receptor, as well as several other lymphokines. Cyclosporine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus