Title : TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration.

Pub. Date : 2015 Jul 1

PMID : 25930080






1 Functional Relationships(s)
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1 In a chronic-binge ethanol-feeding model, the TLR2 and TLR9-dependent MyD88-dependent pathway mediates CXCL1 production in hepatocytes and HSCs; the CXCL1 then promotes neutrophil infiltration into the liver via CXCR2, resulting in the development of alcohol-mediated liver injury. Alcohols myeloid differentiation primary response gene 88 Mus musculus