Pub. Date : 2015 Jun 15
PMID : 25928802
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study is to explain, from a mechanistic point of view, the clinical evidence showing a significant role of glutathione-S-transferase (GST)-M1 genotype on AZA toxicity in inflammatory bowel disease patients. | Azathioprine | glutathione S-transferase kappa 1 | Homo sapiens |
| 2 | The aim of this study is to explain, from a mechanistic point of view, the clinical evidence showing a significant role of glutathione-S-transferase (GST)-M1 genotype on AZA toxicity in inflammatory bowel disease patients. | Azathioprine | glutathione S-transferase kappa 1 | Homo sapiens |
| 3 | In this study, an in vitro model to study thiopurines" metabolism has been set up and helped us to demonstrate, for the first time, a clear role of GST-M1 in modulating AZA cytotoxicity, with a close dependency on superoxide anion production. | Azathioprine | glutathione S-transferase kappa 1 | Homo sapiens |
| 4 | These results provide the molecular basis to shed light on the clinical evidence suggesting a role of GST-M1 genotype in influencing the toxic effects of AZA treatment. | Azathioprine | glutathione S-transferase kappa 1 | Homo sapiens |