Title : Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens.

Pub. Date : 2015 Jul

PMID : 25921217






2 Functional Relationships(s)
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1 Salpichrolides are natural plant steroids that contain an unusual six-membered aromatic ring D. We recently reported that some of these compounds, and certain analogs with a simplified side chain, exhibited antagonist effects toward the human estrogen receptor (ER), a nuclear receptor whose endogenous ligand has an aromatic A ring (estradiol). Steroids estrogen receptor 1 Homo sapiens
2 Salpichrolides are natural plant steroids that contain an unusual six-membered aromatic ring D. We recently reported that some of these compounds, and certain analogs with a simplified side chain, exhibited antagonist effects toward the human estrogen receptor (ER), a nuclear receptor whose endogenous ligand has an aromatic A ring (estradiol). Steroids estrogen receptor 1 Homo sapiens