Pub. Date : 2015 Apr 24
PMID : 25908095
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38). | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38). | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Blocking p38 MAPK activation prevents REGgamma elevation in HaCaT cells with TPA treatment. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | AP-1, the downstream effector of MAPK/p38, directly binds to the REGgamma promoter and activates its transcription in response to TPA stimulation. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 14 | Homo sapiens |