Title : Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells.

Pub. Date : 2015 Jun

PMID : 25907295






2 Functional Relationships(s)
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1 A dose-response curve was generated for itraconazole and clarithromycin (maximal concentration 100 muM) and compared to that of Zosuquidar, a highly specific known P-gp inhibitor. Itraconazole latexin Homo sapiens
2 The respective maximal inhibitory concentrations of Zosuquidar, itraconazole, and clarithromycin prior to induction of cytotoxicity were 0.31, 3.13, and 1.56 muM, respectively, as demonstrated by a statistically significant increase in total intracellular fluorescence (p < 0.05 in all groups). Itraconazole latexin Homo sapiens