Pub. Date : 2015
PMID : 25906044
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, two- and three-dimensional quantitative structure-activity relationship (2D and 3D-QSAR) analyses were performed on a series of pyridine and pyrimidine-based BTK inhibitors by means of genetic algorithm optimized multivariate adaptive regression spline (GA-MARS) and comparative molecular similarity index analysis (CoMSIA) methods. | pyrimidine | Bruton tyrosine kinase | Homo sapiens |
| 2 | Twenty-five pyridine and pyrimidine derivatives as novel potential BTK inhibitors were finally selected for further study. | pyrimidine | Bruton tyrosine kinase | Homo sapiens |