Pub. Date : 2015
PMID : 25904916
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KCa3.1/IK1 Channel Regulation by cGMP-Dependent Protein Kinase (PKG) via Reactive Oxygen Species and CaMKII in Microglia: An Immune Modulating Feedback System? | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 2 | The same site is potentially phosphorylated by cGMP kinase (PKG), and in some cells, PKG can increase Ca(2+), CaM activation, and ROS. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 3 | The same site is potentially phosphorylated by cGMP kinase (PKG), and in some cells, PKG can increase Ca(2+), CaM activation, and ROS. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 4 | Elevating cGMP increased both the KCa3.1 current and intracellular ROS production, and both were prevented by the selective PKG inhibitor, KT5823. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 5 | The cGMP/PKG-evoked increase in KCa3.1 current in intact MLS-9 microglia was mediated by ROS, mimicked by applying hydrogen peroxide (H2O2), inhibited by a ROS scavenger (MGP), and prevented by a selective CaMKII inhibitor (mAIP). | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 6 | The cGMP/PKG-evoked increase in KCa3.1 current in intact MLS-9 microglia was mediated by ROS, mimicked by applying hydrogen peroxide (H2O2), inhibited by a ROS scavenger (MGP), and prevented by a selective CaMKII inhibitor (mAIP). | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |