Pub. Date : 2015 Jun
PMID : 25891879
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AST IV inhibits H2O2-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-beta1/Smad2 pathway. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 2 | We demonstrated that hydrogen peroxide (H2O2) increased Nox4-dependent-ROS aggregation, as well as the expression of TGF-beta1, Smad2, Bax and caspase-3, decreased Bcl-2 expression and increased the apoptosis of human umbilical vein endothelial cells (HUVECs). | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 3 | We demonstrated that hydrogen peroxide (H2O2) increased Nox4-dependent-ROS aggregation, as well as the expression of TGF-beta1, Smad2, Bax and caspase-3, decreased Bcl-2 expression and increased the apoptosis of human umbilical vein endothelial cells (HUVECs). | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |
| 4 | Taken together, the findings of the present study suggest that H2O2 contributes to HUVEC apoptosis by inducing Nox4-dependent ROS aggregation and activating the TGF-beta1/Smad2 signaling pathway. | Hydrogen Peroxide | transforming growth factor beta 1 | Homo sapiens |