Pub. Date : 2015 Apr
PMID : 25891728
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunohistochemistry and Western blot analysis data revealed that the FK506 treatment increased expression of heme oxygenase-1 (HO-1) in Jurkat cells in a dose-dependent manner. | Tacrolimus | heme oxygenase 1 | Homo sapiens |
| 2 | Immunohistochemistry and Western blot analysis data revealed that the FK506 treatment increased expression of heme oxygenase-1 (HO-1) in Jurkat cells in a dose-dependent manner. | Tacrolimus | heme oxygenase 1 | Homo sapiens |
| 3 | HO-1 expression was induced after 6 hours of treatment of FK506 to Jurkat cells, peaked at 24 hours, and then decreased after 48 hours. | Tacrolimus | heme oxygenase 1 | Homo sapiens |
| 4 | CONCLUSIONS: These results suggest that FK506 induces Nrf 2-driven transcriptional activation of the antioxidant response element by activating HO-1 and free radicals such as reactive oxygen species and nitric oxide. | Tacrolimus | heme oxygenase 1 | Homo sapiens |