Pub. Date : 2015 Jul
PMID : 25891084
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In this study, we investigated how diltiazem altered the relationship between MDR1 genetic polymorphisms and CsA concentration in Chinese patients with renal transplantation. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | With regard to MDR1-3435, the adjusted CsA trough concentration was significantly higher in TT carriers than in CC and CT carriers when diltiazam was co-administered (58.83+-13.95 versus 46.14+-7.55 and 45.18+-12.35 ng/mL per mg/kg, P=0.011), and the differences were not observed in patients without diltiazam co-administered. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | With regard to MDR1-2677, the adjusted CsA trough concentration was significantly higher in TT carriers than in GG and GT carriers when diltiazam was co-administered (61.31+-12.93 versus 52.25+-7.83 and 39.70+-7.26 ng/mL per mg/kg, P=0.0001). | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSION: MDR1 variants influence the adjusted CsA trough concentration in Chinese patients with renal transplant, and the influence more prominent when diltiazem is co-administered. | Cyclosporine | ATP binding cassette subfamily B member 1 | Homo sapiens |