Title : Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.

Pub. Date : 2015 Mar 7

PMID : 25888415






2 Functional Relationships(s)
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1 Co-administration of olaparib and SAHA synergistically inhibited the growth of TNBC cells that expressed functional Phosphatase and tensin homolog (PTEN). olaparib phosphatase and tensin homolog Homo sapiens
2 CONCLUSION: Our findings suggest that expression of functional PTEN may serve as a biomarker for selecting TNBC patients that would favorably respond to a combination of olaparib with SAHA. olaparib phosphatase and tensin homolog Homo sapiens