Pub. Date : 2015 Mar 9
PMID : 25887954
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: LPS induced apoptosis in adult mouse ventricular myocytes, dobutamine (DOB), a beta1-AR agonist, promoted apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca(2+) concentration in LPS-challenged cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |
| 2 | RESULTS: LPS induced apoptosis in adult mouse ventricular myocytes, dobutamine (DOB), a beta1-AR agonist, promoted apoptosis, caspase-8, 9 and 3 activation and increased cytosolic Ca(2+) concentration in LPS-challenged cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |
| 3 | DOB also up-regulated TNF-alpha expression, decreased Bcl-2 levels, promoted Bax translocation to mitochondria, mitochondrial membrane potential loss and cytochrome c release as well as IkappaBalpha, p38 MAPK, JNK and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphorylation in LPS-treated cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |
| 4 | Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |
| 5 | Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |
| 6 | Pretreatment with nifedipine not only significantly blocked the enhancing effects of DOB on LPS-induced elevation in cytosolic Ca(2+) concentration and CaMKII phosphorylation in cardiomyocytes, but also partly reversed the effects of DOB on caspase-9 and caspase-3/7 activities in LPS-treated cardiomyocytes. | Dobutamine | toll-like receptor 4 | Mus musculus |