Title : Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats.

Pub. Date : 2015 Mar 8

PMID : 25885968






1 Functional Relationships(s)
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1 Real-time PCR and Western blot analysis of the female brain revealed that DOCA/salt treatment enhanced the mRNA and protein expression for both antihypertensive components including AT2-R, angiotensin-converting enzyme (ACE)-2, and interleukin (IL)-10 and hypertensive components including angiotensin receptor type 1 (AT1-R), ACE-1, tumor necrosis factor (TNF)-alpha, and IL-1beta, but decreased mRNA expression of renin in the PVN. Desoxycorticosterone Acetate angiotensin II receptor, type 1a Rattus norvegicus