Title : Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGF expression: implications for stroke.

Pub. Date : 2015

PMID : 25884837






2 Functional Relationships(s)
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1 Our findings demonstrated that treatment of human brain microvascular pericytes with sodium cyanide (NaCN) and glucose deprivation resulted in increased expression of vascular endothelial growth factor (VEGF) via the activation of tyrosine kinase Src, with downstream activation of mitogen activated protein kinase and PI3K/Akt pathways and subsequent translocation of NF-kappaB into the nucleus. Sodium Cyanide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Our findings demonstrated that treatment of human brain microvascular pericytes with sodium cyanide (NaCN) and glucose deprivation resulted in increased expression of vascular endothelial growth factor (VEGF) via the activation of tyrosine kinase Src, with downstream activation of mitogen activated protein kinase and PI3K/Akt pathways and subsequent translocation of NF-kappaB into the nucleus. Sodium Cyanide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens