Pub. Date : 2015 Jul
PMID : 25881750
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 2 | We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 3 | We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 4 | Through activation of HCAR1, lactate can act as a volume transmitter that links neuronal activity, cerebral blood flow, energy metabolism, and energy substrate availability, including a glucose- and glycogen-saving response. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 5 | In addition to locally produced lactate, lactate produced by exercising muscle as well as exogenous HCAR1 agonists, e.g., from fruits and berries, might activate the receptor on cerebral blood vessels and brain cells. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |