Title : Drivers of age-related inflammation and strategies for healthspan extension.

Pub. Date : 2015 May

PMID : 25879284






1 Functional Relationships(s)
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1 The NLRP3 inflammasome is especially relevant to aging as it can get activated in response to structurally diverse damage-associated molecular patterns (DAMPs) such as extracellular ATP, excess glucose, ceramides, amyloids, urate, and cholesterol crystals, all of which increase with age. Cholesterol NLR family pyrin domain containing 3 Homo sapiens