Title : In vitro and in vivo action of diisopropylfluorophosphate, of atropine and their synergism on acetylcholinesterase activity.

Pub. Date : 1989

PMID : 2587621






6 Functional Relationships(s)
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1 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Atropine acetylcholinesterase Rattus norvegicus
2 Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. Atropine acetylcholinesterase Rattus norvegicus
3 In vitro atropine caused a reduction of the AChE activity, but reduced the enzyme inhibition by DFP. Atropine acetylcholinesterase Rattus norvegicus
4 In vivo the AChE inhibition by DFP is in part reduced by atropine. Atropine acetylcholinesterase Rattus norvegicus
5 The limited protection of AChE by atropine may be one of the factors implied in the reduction of the DFP toxicity by atropine. Atropine acetylcholinesterase Rattus norvegicus
6 The limited protection of AChE by atropine may be one of the factors implied in the reduction of the DFP toxicity by atropine. Atropine acetylcholinesterase Rattus norvegicus