Title : PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK/AKT/NF-κB-dependent pathway.

Pub. Date : 2016 Jan

PMID : 25876056






2 Functional Relationships(s)
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1 However, N-acetylcysteine (NAC), a scavenger of ROS, prevented the increase of ROS generation, attenuated the phosphorylation of the above kinases, and decreased the NF-kappaB activation as well as the expression of ICAM-1 and VCAM-1. Reactive Oxygen Species vascular cell adhesion molecule 1 Homo sapiens
2 These findings suggest PM2.5 -induced ROS may function as signaling molecules triggering ICAM-1 and VCAM-1 expressions through activating the ERK/AKT/NF-kappaB-dependent pathway, and further promoting monocyte adhesion to endothelial cells. Reactive Oxygen Species vascular cell adhesion molecule 1 Homo sapiens