Pub. Date : 2015 Jul 15
PMID : 25869780
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Furthermore, flupirtine (10mg/kg and 25mg/kg) treatment significantly decreased the expression of Bax and increased the p-Akt and p-GSK-3beta, and flupirtine (25mg/kg) treatment up-regulated the p-Erk1/2 in the hippocampus of CRS mice. | flupirtine | mitogen-activated protein kinase 3 | Mus musculus |
2 | These results suggested that flupirtine exerted protective effects on the CRS-induced cognitive impairment and hippocampal neuronal apoptosis, which is possibly associated with the activation of Akt/GSK-3beta and Erk1/2 signaling pathways. | flupirtine | mitogen-activated protein kinase 3 | Mus musculus |