Title : Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.

Pub. Date : 2015 Jul 15

PMID : 25869780






2 Functional Relationships(s)
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1 Furthermore, flupirtine (10mg/kg and 25mg/kg) treatment significantly decreased the expression of Bax and increased the p-Akt and p-GSK-3beta, and flupirtine (25mg/kg) treatment up-regulated the p-Erk1/2 in the hippocampus of CRS mice. flupirtine mitogen-activated protein kinase 3 Mus musculus
2 These results suggested that flupirtine exerted protective effects on the CRS-induced cognitive impairment and hippocampal neuronal apoptosis, which is possibly associated with the activation of Akt/GSK-3beta and Erk1/2 signaling pathways. flupirtine mitogen-activated protein kinase 3 Mus musculus