Pub. Date : 2015 Jul
PMID : 25869056
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide suppresses melanin synthesis through Akt/GSK3beta/beta-catenin signal pathway. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | 6-Bromoindirubin-3"-oxime (BIO, inhibitor of GSK3beta) and insulin-like growth factors-1 (IGF-1, activator of Akt) could reverse the decline of beta-catenin in B16F10 cells induced by andrographolide. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSION: These results demonstrate that andrographolide can effectively suppress melanin content and TYR activity in B16F10 cells, HEM cells and UVB-induced brown guinea pig skin by decreasing phosphorylation of GSK3beta dependent on Akt, promoting the degradation of beta-catenin, inhibiting beta-catenin into the nucleus and decreasing the expression of MITF and TYR family. | andrographolide | thymoma viral proto-oncogene 1 | Mus musculus |