Title : Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice.

Pub. Date : 2015 Oct 20

PMID : 25867281






2 Functional Relationships(s)
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1 Consistently, cathepsin B was found to proteolytically process pro-IL-1beta to its active form and this activity was suppressed by ROS. Reactive Oxygen Species interleukin 1 beta Mus musculus
2 CONCLUSION: Our results suggest that ROS act as a negative feedback to constrain IL-1beta-mediated inflammation, accounting for the more severe arthritis in the absence of NOX2. Reactive Oxygen Species interleukin 1 beta Mus musculus