Pub. Date : 1989 Nov
PMID : 2586490
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase (FPGS). | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 2 | Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase (FPGS). | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 3 | A series of 2,4-diaminopyrimidine dihydrofolate reductase inhibitors were found to be substrates for FPGS; these are the first known compounds without a fused ring system analogous to the pteridine ring of the folate molecule that are substrates for FPGS. | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 4 | A series of 2,4-diaminopyrimidine dihydrofolate reductase inhibitors were found to be substrates for FPGS; these are the first known compounds without a fused ring system analogous to the pteridine ring of the folate molecule that are substrates for FPGS. | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 5 | It was concluded that neither the 2-amino group nor an intact pyrazine ring of folates and folate analogs are essential for the binding of folates to the active site of mouse liver FPGS but that the pyrazine ring probably serves to position other regions of the folate molecule that interact with amino acid residues in the active site. | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 6 | It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site. | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |
| 7 | It was also inferred from these observations that the volume within the active site of FPGS above/below the pyrazine ring or near the 10-position of folate derivatives are regions of limited bulk tolerance; binding of folate analogs with substituents at these positions probably distorts the active site. | Folic Acid | folylpolyglutamyl synthetase | Mus musculus |