Title : Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

Pub. Date : 2015 Jul

PMID : 25857771






1 Functional Relationships(s)
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1 RESULTS: We show that drug-related compounds, debrisoquine and terfenadine derivatives, subtrates of CYP2D6 and CYP2J2, are hydroxylated by recombinant CYP2U1 with regioselectivities different from those reported for CYP2D6 and 2J2. Terfenadine cytochrome P450 family 2 subfamily J member 2 Homo sapiens