Pub. Date : 2015
PMID : 25854934
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic LTG treatment rescues the suppressed long-term potentiation, loss of spines and cognitive deficits in AbetaPP/PS1 mice, known to overexpress a chimeric mouse/human mutant amyloid-beta protein precursor (AbetaPP) and a mutant human presenilin 1 (PS1). | Lamotrigine | presenilin 1 | Homo sapiens |
| 2 | Chronic LTG treatment rescues the suppressed long-term potentiation, loss of spines and cognitive deficits in AbetaPP/PS1 mice, known to overexpress a chimeric mouse/human mutant amyloid-beta protein precursor (AbetaPP) and a mutant human presenilin 1 (PS1). | Lamotrigine | presenilin 1 | Homo sapiens |
| 3 | In this study, decreased protein levels, but not mRNA levels of beta-site AbetaPP-cleaving enzyme 1 (BACE1), were observed in cultured HEK293 cells and the brains of AbetaPP/PS1 transgenic mice upon LTG treatment. | Lamotrigine | presenilin 1 | Homo sapiens |