Title : IL-2 induction of IL-1 beta mRNA expression in monocytes. Regulation by agents that block second messenger pathways.

Pub. Date : 1989 Dec 1

PMID : 2584705






1 Functional Relationships(s)
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1 LPS induction of IL-1 beta mRNA in human monocytes can be blocked by either an inhibitor of protein kinase C (PKc) 1-(5-isoquinolinesulfonyl)-2-methylpiperazine or an inhibitor of calcium/calmodulin (CaM) kinase N-(6-aminohexyl) 5-chloro-1-naphthalenesulfonamide, suggesting that both PKc and CaM kinase are involved in transducing signals initiated by LPS. W 7 interleukin 1 beta Homo sapiens