Pub. Date : 2015 Jul
PMID : 25846811
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found an inverse correlation between the intensity of ERK activity and the degree of AMPK activation after stimulation with either glucose deprivation or metformin. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We also found that the inhibition of ERK activity by U0126 restored AMPK activation after metformin treatment. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Importantly, metformin induced ERK activation by suppressing the protein levels of dual specificity phosphatase 6, a negative regulator of ERK. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Importantly, metformin induced ERK activation by suppressing the protein levels of dual specificity phosphatase 6, a negative regulator of ERK. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | This crosstalk between AMPK and ERK could diminish the antileukemic activity of metformin. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |