Title : ObRb downregulation increases breast cancer cell sensitivity to tamoxifen.

Pub. Date : 2015 Sep

PMID : 25846733






1 Functional Relationships(s)
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1 This study suggested that long-term endocrine therapy facilitates leptin and ObRb overexpression in breast cancer cells, which attenuates the inhibitory effect of tamoxifen by activating both the ERK1/2 and STAT3 signaling pathways and upregulating CCND1 gene expression. Tamoxifen cyclin D1 Homo sapiens