Title : Synthesis of trans-16-triazolyl-13α-methyl-17-estradiol diastereomers and the effects of structural modifications on their in vitro antiproliferative activities.

Pub. Date : 2015 Jun

PMID : 25845933






1 Functional Relationships(s)
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1 Novel 16-triazoles in the 13alpha-estrone series were synthesized via Cu(I)-catalyzed azide-alkyne cycloaddition of the two diastereomeric (on C-16 and on C-17) 16-azido-13alpha-estra-1,3,5(10)-trien-17-ol 3-benzyl ethers with substituted phenylacetylenes. Carbon cytokine like 1 Homo sapiens