Pub. Date : 2015
PMID : 25835505
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | These include competition with chloride, the natural co-substrate; switching the MPO activity from a two electron oxidation to a one electron pathway causing the buildup of the inactive Compound II, and its subsequent decay to MPO-Fe(III) instead of generating HOCl; binding to MPO above the heme iron, thereby preventing the access of H2O2 to the catalytic site of the enzyme; and direct scavenging of HOCl. | Chlorides | myeloperoxidase | Homo sapiens |