Title : Perinatal asphyxia leads to PARP-1 overactivity, p65 translocation, IL-1β and TNF-α overexpression, and apoptotic-like cell death in mesencephalon of neonatal rats: prevention by systemic neonatal nicotinamide administration.

Pub. Date : 2015 May

PMID : 25835215






3 Functional Relationships(s)
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Protein Name
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1 A single dose of the PARP-1 inhibitor nicotinamide (0.8 mmol/kg, i.p. Niacinamide poly (ADP-ribose) polymerase 1 Rattus norvegicus
2 The present study demonstrates that PA leads to PARP-1 overactivation, increasing the expression of pro-inflammatory cytokines and cell death in mesencephalon, effects prevented by systemic neonatal nicotinamide administration, supporting the idea that PARP-1 inhibition represents a therapeutic target against the effects of PA. Niacinamide poly (ADP-ribose) polymerase 1 Rattus norvegicus
3 The present study demonstrates that PA leads to PARP-1 overactivation, increasing the expression of pro-inflammatory cytokines and cell death in mesencephalon, effects prevented by systemic neonatal nicotinamide administration, supporting the idea that PARP-1 inhibition represents a therapeutic target against the effects of PA. Niacinamide poly (ADP-ribose) polymerase 1 Rattus norvegicus